The PD‐1 Interactome
نویسندگان
چکیده
منابع مشابه
The Mammalian Septin Interactome
Septins are GTP-binding and membrane-interacting proteins with a highly conserved domain structure involved in various cellular processes, including cytoskeleton organization, cytokinesis, and membrane dynamics. To date, 13 different septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14), which can be classified into four distinct subgroups based on the sequence homology of t...
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The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beg...
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Despite successes, thus far, a significant proportion of the patients treated with anti-PD1 antibodies have failed to respond. We use mouse tumor models of anti-PD1 sensitivity and resistance and flow cytometry to assess tumor-infiltrating immune cells immediately after therapy. We demonstrate that the expression levels of T-cell PD1 (PD1(lo)), myeloid, and T-cell PDL1 (PDL1(hi)) in the tumor m...
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The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks. Here, we perform a comprehensive analysis of yeast PPI networks in orde...
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Motivations Protein interaction databases archive proteinprotein interaction (PPI) information from published articles. However, no database alone has sufficient literature coverage to offer a complete resource to investigate “the interactome”. We have developed mentha, a new resource that addresses this problem. mentha archives evidence about PPI in the human proteome evidence collected from d...
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ژورنال
عنوان ژورنال: Advanced Biology
سال: 2021
ISSN: 2701-0198,2701-0198
DOI: 10.1002/adbi.202100758